CONTENTS

In Japanese


—Symposium Reviews—

Forefront Researches of Drug Innovation Technology in the Post-genomic Era—Studies of Biomarker Discovery for Drug Development—
……… K. Nagano, H. Nabeshi, and S. Tsunoda 463
Safety Assessment of Nanomaterials Using Toxicokinetics and Toxicoproteome Analysis
……… H. Nabeshi, T. Yoshikawa, T. Imazawa, S. Tsunoda, and Y. Tsutsumi 465
New Functional Proteins Identified by Proteomic Analysis in the Epidermal Growth Factor Receptor-mediated Signaling Pathway and Application for Practical Use
……… K. Tashiro, H. Konishi, H. Nabeshi, E. Yamauchi, and H. Taniguchi 471
Development of Anti-tumor Blood Vessel Antibodies by Phage Display Method
……… T. Yamashita, N. Utoguchi, R. Suzuki, K. Nagano, S. Tsunoda, Y. Tsutsumi, and K. Maruyama 479
From Disease Proteomics to Biomarker Development—Establishment of Antibody Proteomics Technology and Exploration of Cancer-related Biomarkers—
……… K. Nagano, S. Imai, S. Nakagawa, S. Tsunoda, and Y. Tsutsumi 487
Elucidation of Mechanism Underlying Amyloid-β Peptide Aggregation and Its Neurotoxicity Expression and Inhibition of These Molecular Processes by Beneficial Synthetic and Natural Compounds with Low-molecular Weights—New Approaches to Fundamental Treatment and Prevention of Alzheimer's Disease—
……… T. Yamakuni 493
Conformational Regulation of Amyloid β-peptide by Lipid Membranes and Metal Ions
……… T. Miura, M. Yoda, C. Tsutsumi, K. Murayama, and H. Takeuchi 495
A Search for Antiamyloidogenic Compounds Based on a Nucleation-Dependent Polymerization Model
……… H. Naiki, K. Hasegawa, K. Ono, and M. Yamada 503
Ganglioside Cluster-mediated Aggregation and Cytotoxicity of Amyloid β-Peptide: Molecular Mechanism and Inhibition
……… K. Matsuzaki 511
Preventive Action of Nobiletin, a Constituent of AURANTII NOBILIS PERICARPIUM with Anti-dementia Activity, against Amyloid-β Peptide-induced Neurotoxicity Expression and Memory Impairment
……… T. Yamakuni, A. Nakajima, and Y. Ohizumi 517
Development of Anti-Alzheimer's Disease Drug Based on Beta-Amyloid Hypothesis
……… H. Sugimoto 521
Development of Novel Cell Culture Systems and Their Application to Pharmaceutical Research
……… A. Taniguchi and T. Takezawa 527
Development of Novel Culture System Using Nano-biotechnology
……… A. Taniguchi, K. Wada, and M. Ohno 529
Development of Novel Culture System for Regulation of Hepatocyte Function
……… K. Yagi, M. Kawase, K. Isoda, and M. Kondoh 537
On-chip Cellomics Technology for Drug Screening System Using Cardiomyocyte Cells from Human Stem Cell
……… K. Yasuda 545
Cellular Engineering and Biosensor Technology for High Through-put Analysis on Drug Discovery
……… T. Haruyama 559
Development of Novel Cell Culture Systems Utilizing the Advantages of Collagen Vitrigel Membrane
……… T. Takezawa, M. Fukuda, W. Mcintosh-Ambrose, J.-A. Ko, J. Elisseeff, S. Haga, M. Ozaki, K. Kato, P.-C. Wang, T. Uchino, and T. Nishida 565
Pharmaceutical Science in Acute Care that Requires Clinical Sense
……… K. Ooi and N. Takamura 575
The Roles of Pharmacists in Cardiopulmonary Resuscitation (CPR)
……… H. Kawara, Y. Tokuyama, and Y. Shimizu 577
Life-support Training to Improve the Clinical Competence of Pharmacy Students
……… N. Takamura, J. Tokunaga, K. Ogata, H. Yoshida, and N. Setoguchi 583
Possible Role of Pharmacists in Emergency Medical Care
……… T. Takeda 589

—Regular Articles—

Cost-effectiveness of Salmeterol/Fluticasone Combination Therapy vs. Fluticasone Propionate in Japanese Asthmatic Patients
……… Y. Tohda, S. Nishima, I. Arakawa, M. Shiragami, and T. Miyamoto 593
Proposition and Evaluation of the Educational Activities for Effective Utilization of Opioids Performed by Pharmacists in Palliative Home Care
……… N. Akai, D. Hashimoto, T. Fujita, K. Miyake, W. Hamabe-Fujita, and S. Tokuyama 605
Estimating Pediatric Doses of Drugs Metabolized by Cytochrome P450 (CYP) Isozymes, Based on Physiological Liver Development and Serum Protein Levels
……… S. Suzuki, Y. Murayama, E. Sugiyama, V. Hirunpanich, K. Saito, M. Sekiyama, and H. Sato 613

—Articles—

The Optimal Volume of Medicinal Solution in the Portable Disposable Infusion Pump (SUREFUSER®A) for FOLFOX6, FOLFIRI Therapy of Colorectal Cancer Patients (2nd Report) - Influence of Temperature on Outflow Speed of the Medicinal Solution
……… Y. Kawabata and A. Nakagawa 621