CONTENTS

In Japanese


—Symposium Reviews—

New Development of Histamine Research on the Inflammation
………M. Akagi and H. Fukui 169
Histamine H1 Receptor Gene as an Allergic Diseases-sensitive Gene and Its Impact on Therapeutics for Allergic Diseases
………H. Mizuguchi, Y. Kitamura, Y. Kondo, W. Kuroda, H. Yoshida, Y. Miyamoto, M. Hattori, N. Takeda, and H. Fukui 171
Roles of Histamine in the Exacerbated Allergic Dermatitis
………N. Hirasawa and K. Ohuchi 179
Roles of Histamine in the Pathogenesis of Bronchial Asthma and Reevaluation of the Clinical Usefulness of Antihistamines
………K. Yamauchi, T. Shikanai, Y. Nakamura, H. Kobayashi, M. Ogasawara, and K. Maeyama 185
Recent Topics of NanoTox Studies for Their Safety
………Y. Tsutsumi and Y. Yoshioka 193
Importance of Researches on Chronic Effects by Manufactured Nanomaterials
………A. Hirose, A. Takagi, T. Nishimura, H. Tsuda, Y. Sakamoto, A. Ogata, D. Nakae, O. Hino, and J. Kanno 195
Transdermal Penetration and Biodistribution of Nanomaterials and Their Acute Toxicity in Vivo
………S. Tsunoda 203
Development of NanoSafety Forecasting System from the Viewpoint of Nanomaterial-protein Interaction
………T. Yoshikawa 209
Safety Studies of Nanomaterials about Intracellular Distribution and Genotoxicity
………Y. Abe 215
NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity
………Y. Yoshioka 221
Biodistribution of Nanosilica Particles in Pregnant Mice and the Potential Risk on the Reproductive Development
………K. Nagano 225
Health Effects of Nanomaterials on Next Generation
………K. Takeda, Y. Shinkai, K. Suzuki, S. Yanagita, M. Umezawa, S. Yokota, H. Tainaka, S. Oshio, T. Ihara, and M. Sugamata 229
Pharmacogenomics Study to Avoid Serious Drug Adverse Reactions
………R. Hasegawa and M. Iwasaki 237
Pharmacogenomic Research for Avoiding Adverse Reactions by Anti-cancer Drugs
………Y. Saito 239
Genetic Marker of Statin-induced Rhabdomyolysis
………K. Chiba and K. Morimoto 247
Exploratory Study on Biomarkers Associated with Severe Cutaneous Adverse Reactions
………N. Kaniwa 255
Current Status of Researches in Genomic Medicine and the Guidelines for Pharmacogenomics (PGx)
………N. Kamatani 263

—Reviews—

Natural Products Syntheses Based on the Biotransformation Using Biocatalyst
………H. Akita 269
Development of Highly Nuclease-resistant Chemically-modified Oligonucleotides
………A. Matsuda 285
Development of Animal Models of Herpetic Pain and Postherpetic Neuralgia and Elucidation of the Mechanisms of the Onset and Inhibition of Allodynia
………I. Takasaki 299

—Regular Article—

Effects of Sperminated Pullulans on the Pulmonary Absorption of Insulin
………T. Seki, N. Fukushi, H. Maru, S. Kimura, S. Chono, Y. Egawa, K. Morimoto, H. Ueda, and Y. Morimoto 307