CONTENTS

In Japanese


—Symposium Reviews—

New Development of Histamine Research on the Inflammation
………M. Akagi and H. Fukui …169
Histamine H1 Receptor Gene as an Allergic Diseases-sensitive Gene and Its Impact on Therapeutics for Allergic Diseases
………H. Mizuguchi, Y. Kitamura, Y. Kondo, W. Kuroda, H. Yoshida, Y. Miyamoto, M. Hattori, N. Takeda, and H. Fukui …171
Roles of Histamine in the Exacerbated Allergic Dermatitis
………N. Hirasawa and K. Ohuchi …179
Roles of Histamine in the Pathogenesis of Bronchial Asthma and Reevaluation of the Clinical Usefulness of Antihistamines
………K. Yamauchi, T. Shikanai, Y. Nakamura, H. Kobayashi, M. Ogasawara, and K. Maeyama …185
Recent Topics of NanoTox Studies for Their Safety
………Y. Tsutsumi and Y. Yoshioka …193
Importance of Researches on Chronic Effects by Manufactured Nanomaterials
………A. Hirose, A. Takagi, T. Nishimura, H. Tsuda, Y. Sakamoto, A. Ogata, D. Nakae, O. Hino, and J. Kanno …195
Transdermal Penetration and Biodistribution of Nanomaterials and Their Acute Toxicity in Vivo
………S. Tsunoda …203
Development of NanoSafety Forecasting System from the Viewpoint of Nanomaterial-protein Interaction
………T. Yoshikawa …209
Safety Studies of Nanomaterials about Intracellular Distribution and Genotoxicity
………Y. Abe …215
NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity
………Y. Yoshioka …221
Biodistribution of Nanosilica Particles in Pregnant Mice and the Potential Risk on the Reproductive Development
………K. Nagano …225
Health Effects of Nanomaterials on Next Generation
………K. Takeda, Y. Shinkai, K. Suzuki, S. Yanagita, M. Umezawa, S. Yokota, H. Tainaka, S. Oshio, T. Ihara, and M. Sugamata …229
Pharmacogenomics Study to Avoid Serious Drug Adverse Reactions
………R. Hasegawa and M. Iwasaki …237
Pharmacogenomic Research for Avoiding Adverse Reactions by Anti-cancer Drugs
………Y. Saito …239
Genetic Marker of Statin-induced Rhabdomyolysis
………K. Chiba and K. Morimoto …247
Exploratory Study on Biomarkers Associated with Severe Cutaneous Adverse Reactions
………N. Kaniwa …255
Current Status of Researches in Genomic Medicine and the Guidelines for Pharmacogenomics (PGx)
………N. Kamatani …263

—Reviews—

Natural Products Syntheses Based on the Biotransformation Using Biocatalyst
………H. Akita …269
Development of Highly Nuclease-resistant Chemically-modified Oligonucleotides
………A. Matsuda …285
Development of Animal Models of Herpetic Pain and Postherpetic Neuralgia and Elucidation of the Mechanisms of the Onset and Inhibition of Allodynia
………I. Takasaki …299

—Regular Article—

Effects of Sperminated Pullulans on the Pulmonary Absorption of Insulin
………T. Seki, N. Fukushi, H. Maru, S. Kimura, S. Chono, Y. Egawa, K. Morimoto, H. Ueda, and Y. Morimoto …307