CONTENTS

In Japanese


—Symposium Reviews—

Frontiers of Ca2+ Signaling ∼Physiological and Pathological Roles of Voltage-independent Ca2+ Channels∼
……… M. Nishida 279
Pathophysiological Roles of Transient Receptor Potential Channels in Glial Cells
……… H. Shirakawa, T. Nakagawa, and S. Kaneko 281
Activation and Regulation of Nociceptive Transient Receptor Potential (TRP) Channels, TRPV1 and TRPA1
……… M. Tominaga 289
Mechanism of Cardiac Hypertrophy via Diacylglycerol-sensitive TRPC Channels
……… M. Nishida, K. Watanabe, M. Nakaya, and H. Kurose 295
Pharmacological Properties of Novel TRPC Channel Inhibitors
……… S. Kiyonaka, K. Kato, M. Nishida, and Y. Mori 303
Principle and Practice of Fragment Based Lead Discovery
……… A. Yamano 313
Fragment-based Drug Discovery: Concept and Aim
……… D. Tanaka 315
NMR Screening in the Fragment-based Drug Discovery
……… H. Hanzawa and T. Takizawa 325
Fragment-based Screening by X-ray Structure Analysis
……… A. Yamano 335
Fragment Screening Using Surface Plasmon Resonance Optical Biosensor Technology
……… T. Miura 341
In Silico Approaches for Fragment-based Drug Design
……… O. Takahashi, Y. Masuda, A. Muroya, and T. Furuya 349

—Reviews—

Design, Synthesis and Evaluation of Polyamide-nucleoside Hybrids and Oligonucleotides Conjugated Hybrid as a Novel Gene Expression Control Compound
……… E. Kawashima and K. Kamaike 355
Identification of Novel Molecules Regulating Differentiation and Hormone Secretion and Clarification of Their Functional Mechanisms in Pancreatic Endocrine Cells
……… T. Oka, M. Ohtani, and J. Suzuki 377

—Regular Articles—

A Survey of Difference in Appearance between Multiple-specifications Press-through-package Drug Products and an Attempt to Evaluate Their Effectiveness Based on Dispensing Incidents
……… N. Kamimura, T. Shiokawa, A. Yogi, S. Akazawa, N. Shimazaki, and T. Ohta 389
Preparation and in Vitro, in Vivo Characterization of Elastic Liposomes Encapsulating Cyclodextrin-Colchicine Complexes for Topical Delivery of Colchicine
……… H. P. Singh, A. K. Tiwary, and S. Jain 397
Crystalline Drug Aconitine-loaded Poly(d,l-Lactide-CoGlycolide) Nanoparticles: Preparation and in Vitro Release
……… X. Xu, Q. Xiang, Z. He, Y. Liu, D. Zhou, X. Qin, T. Fan, Z. Zhang, and Y. Huang 409
Methazolamide Calcium Phosphate Nanoparticles in an Ocular Delivery System
……… R. Chen, Y. Qian, R. Li, Q. Zhang, D. Liu, M. Wang, and Q. Xu 419
An Investigation into the Mechanisms of Rapid Release of Standard Extract from Ginkgo biloba leaf in Polyethylene Glycol 6000 Solid Dispersions
……… Y. Ge 425
Surveillance of Workplace Contamination and Occupational Exposure to Antineoplastic Agents in a Hospital Setting: Establishment of a Monitoring Method Using Doxorubicin
……… K. Matsumoto, T. Naito, K. Hori, N. Suzuki, Y. Miyamoto, Y. Takashina, K. Ohnishi, and J. Kawakami 431

—Notes—

Evaluation of Long-term Practical Training of Graduate Students at an Off-campus Hospital—Questionnaire Survey of Graduate Students and Pharmacists—
……… K. Fukumoto, Y. Fujimura, M. Kusumoto, R. Tatami, and K. Ueno 441
The Study on the Antibacterial Activity of Compounds from the Isodon Species
……… T. Isobe and K. Nagata 447
Histamine Develops Homologous Desensitization under Ca2+-free Conditions with Increase in Basal Tone in Smooth Muscle of Guinea Pig Taenia Caeci
……… S. Hishinuma and M. Shoji 451

—Articles—

Utility and Improvement of Liposome Injections AmBisome® for Clinical Use
……… I. Sugiyama, K. Kudo, K. Takahashi, and Y. Sadzuka 457