CONTENTS

In Japanese


—Symposium Reviews—

Current Trends of Theoretical and Medicinal Chemistry
………H. Tokiwa 1149
Recent Progress in the Theoretical Studies of Structure, Function, and Reaction of Biological Molecules
………H. Hirao and K. Morokuma 1151
Large Scale Quantum Chemical Calculation for Drug Discovery
………K. Kitaura 1163
Modeling the Transition State of Enzyme-catalyzed Phosphoryl Transfer Reaction Using QM/MM Method
………S. Re and Y. Sugita 1171

—Reviews—

Analysis of the Mechanism of Polycythemia Vera by Studying JAK2 Mutant-induced Signaling Pathway
………M. Funakoshi-Tago 1183
Lipin 1 in Lipid Metabolism
………K. Ishimoto 1189
The Cell Surface Protein Ecm33 Is Involved in Negative Feedback Regulation of MAP Kinase Signalling and Development of the In Vivo Real-time Monitoring of MAP Kinase Signalling
………H. Takada 1195
Pathological Role of Apelin in Angiogenic Eye Disease
………A. Kasai 1201
Development of Novel Fluorescence-Derivatization-HPLC Methods Enabling Highly Sensitive and Selective Analysis of Biological Compounds
………K. Todoroki 1207

—Regular Articles—

Meta-Analysis-based Examination regarding the Efficacy of Angiotensin II Receptor Blockers and Calcium Channel Blockers in Borderline Diabetes and Diabetes Patients
………J. Mukai, H. Tada, M. Miura, and K. Mohri 1213
Cross-sectional Study on Relationship between Constipation and Medication in Consideration of Sleep Disorder
………T. Ueki, K. Nagai, Y. Mizukami, A. Takahashi, N. Ooe, M. N. Nakashima, K. Nishida, J. Nakamura, and M. Nakashima 1225
Photometric Study on the Reaction between 2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetrakis-(4-methylpyridyl)porphine and Various Metal Ions
………M. Mifune, A. Iwado, M. Taniguchi, S. Kamino, and S. Enomoto 1233
Effects of Estrogen and Keishibukuryogan on Hot Flash-like Symptoms Induced by Yohimbine in Ovariectomized Rats
………Y. Morimoto, Y. Aozuka, and Y. Shibata 1241

—Note—

Hypertension as a Predictive Factor of Effect of Bevacizumab in Treatment of Colorectal Cancer
………Y. Horinouchi, T. Sakurada, T. Nakamura, S. Tajima, H. Nishisako, S. Abe, K. Teraoka, T. Kujime, K. Kawazoe, and K. Minakuchi 1251