CONTENTS

In Japanese


—Symposium Reviews—

The Power of Young Researcher Responsible for Medicinal Chemistry in Following Generation
………K. Motoshima and R. Shinozaki 315
Nitric Oxide Donors Activated by Two-Photon Excitation
………K. Hishikawa, H. Nakagawa, and N. Miyata 317
Structural Development Study of a Novel Pharmacological Chaperone for Folding-defective Rhodopsin Mutants Responsible for Retinitis Pigmentosa
………K. Ohgane, K. Dodo, and Y. Hashimoto 325
Comprehensive Synthetic Study of Muraymycins toward the Development of Novel Antibacterial Agents
………T. Tanino, S. Ichikawa, K. Uotani, H. Oyama, and A. Matsuda 335
Signi<0136>cance and Creation of Novel Cyclooxygenase-1 (COX-1) Selective Inhibitors
………R. Fukai, X. Zheng, K. Motoshima, and H. Kakuta 347
Molecular Toxicology Led by Young Scientists 5-Biological Systems to Determine the Sensitivity to Chemicals-
………Y. Fujiwara and T. Kimura 353
Studies on Molecular Mechanism of Toxicity of Anticancer Drugs
………T. Takahashi 355
The Mechanism for Subcellular Localization of Nuclear Receptor CAR
………Y. Kanno and Y. Inouye 359
Biology of Diesel Exhaust Effects on Allergic Pulmonary Inflammation
………K. Inoue and H. Takano 367
A Heritage of Pharmacognosy and Its Innovation-Trials from Academic, Investigative and Clinical Perspective
………M. Ito 373
Introduction of “Clinical Pharmacognosy“ -Integration between Pharmacognosy and Clinical Pharmacy-
………T. Makino 375
Recent Progress of International Harmonization of Crude Drugs and Medicinal Plants-Activity of FHH (The Western Pacific Regional Forum for the Harmonization of Herbal Medicines)-
………N. Kawahara 383
History of the Nippon Shinyaku Institute for Botanical Research
………T. Yamaura 395
What Does “Pharmacognosy“ Mean for Pharmacists?
………K. Kawazoe 401

—Reviews—

Clinical Usefulness of Limited Sampling Strategies for Estimating AUC of Proton Pump Inhibitors
………T. Niioka 407
Sex- and Species-differences on Xenobiotic-induced Toxicity: Differences in Constitutive and Xenobiotic-mediated Expression of Cytochrome P450 1A Subfamily Enzymes (CYP1As)
………M. Sekimoto 415

—Regular Articles—

Anti-arthritic Active Fraction of Capparis Spinosa L. Fruits and Its Chemical Constituents
………X. Feng, J. Lu, H. Xin, L. Zhang, Y. Wang, and K. Tang 423
A Special Focus on the Role of α1D-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet
………R. N. Kazi, M. A. Sattar, N. A. Abdullah, M. A. H. Khan, H. A. Rathore, M. H. Abdulla, I. M. Salman, and E. J. Johns 431
Reno-protective Role of Flunarizine (Mitochondrial Permeability Transition Pore Inactivator) against Gentamicin Induced Nephrotoxicity in Rats
………A. Muthuraman, S. K. Singla, A. Rana, A. Singh, and S. Sood 437
Investigation into the Effect of Gastric Secretion Inhibitor for the Prevention of Upper Gastrointestinal Lesions Associated with Low-dose Aspirin
………H. Nakamura, H. Yokoyama, T. Yaguchi, Y. Suzuki, K. Tokuoka, M. Watanabe, Y. Kitagawa, and Y. Yamada 445
Alteration of P-gp Expression after Intestinal Ischemia-reperfusion Following 16-h Fasting in Rats
………J. Ogura, A. Fujikawa, H. Maruyama, M. Kobayashi, S. Itagaki, and K. Iseki 453
Dose Conversion in Opioid Rotation from Continuous Intravenous Infusion of Morphine Hydrochloride Injection to Fentanyl Patch in the Management of Cancer Pain
………C. Kawano, T. Hirayama, and M. Kuroyama 463

—Notes—

Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients
………T. Ueki, K. Nagai, N. Ooe, M. N. Nakashima, K. Nishida, J. Nakamura, and M. Nakashima 469
Educational Effects of Learning through Simulation of Diabetes Drug Therapy
………C. Kikuchi, E. Hori, T. Maeda, T. Matsunaga, and T. Suzuki 477