CONTENTS

In Japanese


—Symposium Reviews—

Signal Transduction in the Development of Vascular Disease and New Therapeutic Strategy
………M. Nishida 1397
Mechanisms for Linking High Salt Intake to Vascular Tone: Role of Na+ Pump and Na+/Ca2+ Exchanger Coupling
………S. Kita and T. Iwamoto 1399
Blood Flow Sensing Mechanism via Calcium Signaling in Vascular Endothelium
………K. Yamamoto and J. Ando 1407
Signaling Mechanism Involved in Regulation of Endothelial Cell-Cell Junctions
………S. Fukuhara and N. Mochizuki 1413
Role of Angiontensin Receptors on Remodeling Perivascular Nerves
………N. Hobara, M. Goda, N. Hashikawa, X. Jin, Y. Zamami, S. Takatori, and H. Kawasaki 1421
Regulation of Cardiovascular Functions by the Phosphorylation of TRPC Channels
………M. Nishida, S. Saiki, N. Kitajima, M. Nakaya, Y. Sato, and H. Kurose 1427
The Frontiers of White Biotechnology and the Development of Pharmaceutical Sciences
………S. Shibasaki and M. Ueda 1435
Novel Bioconversion Systems Using a Yeast Molecular Display System
………S. Shibasaki 1437
Research on Search of the Carotenoid-producing Microorganisms in Marine Area and the Improvement of Production Ratio
………Y. Sakagami, Y. Sumiya, and S. Komemushi 1445
Microbe-inspired System Enzymology of Vitamin B12 Metabolism
………T. Toraya 1453
Novel L-Amino Acid Ligases Catalyzing Oligopeptide Synthesis
………K. Kino 1463
Drug Development from Natural Fermentation Products: Establishing a Manufacturing Process Which Maximizes the Potential of Microorganisms
………K. Nagao, S. Ueda, M. Kanda, N. Oohata, M. Yamashita, and M. Hino 1471
Development of Revolutionary Enzymatic Reactions in Organic Solvents with Molecular Display
………M. Ueda 1479
Development of Cellular and Gene Therapy Products for Bioacitve Protein-based Therapy
………F. Sakurai and M. Nishikawa 1487
Development of Gene Delivery System into Skeletal Muscles by Bubble Liposomes and Ultrasound
………Y. Negishi, Y. Endo-Takahashi, R. Suzuki, K. Maruyama, and Y. Aramaki 1489
Development of Recombinant Adenovirus Carrying MicroRNA-regulated Gene Expression System
………F. Sakurai and H. Mizuguchi 1497
Optimization of Gene Therapy Effect by Spaciotemporal Control of Expressed Proteins
………M. Nishikawa, Y. Takahashi, and Y. Takakura 1505
Gene Therapy with Vector-producing Multipotent Mesenchymal Stromal Cells
………T. Okada 1513
New Technologies for Immunotherapy against Cancer: Development of Cell Expansion Technology and Viruses as Immune Boosters
………Y. Harada and Y. Yonemitsu 1519
Differentiation of Functional Cells from iPS Cells by Efficient Gene Transfer
………K. Kawabata, K. Tashiro, and H. Mizuguchi 1527

—Reviews—

Synthetic Studies towards Kinamycin Antibiotics
………T. Kumamoto 1535
Study for the Novel Factors Regulating Mitochondrial Dynamics
………M. Suenaga 1543

—Regular Articles—

A Systematic Review on the Short-term Efficacy and Safety of Nicorandil for Stable Angina Pectoris in Comparison with Those of β-Blockers, Nitrates and Calcium Antagonists
………Y. Hanai, M. Mita, S. Hishinuma, and M. Shoji 1549
Development of Clinical Pharmacy Services to Improve Drug Adherence in Psychiatric Hospital Patients
………A. Tamaji, A. Sakai, M. Sato, Y. Ikema, K. Matsuzaki, H. Tabuse, and Y. Noda 1565
A Study on Incorporation of “Management and Guidance of Home-visiting by a Pharmacist” into a Care Plan -Observation Based on a Survey of Care Managers-
………Y. Nanaumi, M. Onda, H. Sakurai, R. Tanaka, K. Tsubota, S. Matoba, Y. Mukai, Y. Arakawa, and Y. Hayase 1573
Specific Accumulation and Antitumor Effects of Hybrid Liposomes on the Growth of Lung Tumor Cells
………M. Yukihara, Y. Komizu, O. Tanoue, T. Matsushita, Y. Matsumoto, and R. Ueoka 1581
Mechanism of Interaction between Risperidone and Tea Catechin (1)Complex Formation of Risperidone with Epigallocatechin Gallate
………H. Ikeda, H. Moriwaki, M. Yukawa, Y. Iwase, and H. Aki 1589
Risk Management of QT-prolonging Drugs by Community Pharmacists by Using a Mobile Electrocardiograph
………K. Shinozaki 1597
HPLC Determination of Five Polyphenols in Rat Plasma after Intravenous Administrating Hawthorn Leaves Extract and Its Application to Pharmacokinetic Study
………S.-Y. Wang, J.-Y. Chai, W.-J. Zhang, X. Liu, Y. Du, Z.-Z. Cheng, X.-X. Ying, and T.-G. Kang 1603