CONTENTS

In Japanese


—Symposium Reviews—

The Scientific Basis of Treatment for Infectious Diseases-Appropriate Use of Antibacterial Agents Based on PK-PD Theory-
………J. Kizu and T. Kuroda 1401
Expect for the Pharmacist in the Management of Infectious Diseases
………M. Kaku 1403
Optimization of Antimicrobial Therapy Based on Therapeutic Drug Monitoring
………K. Morita 1407
Appropriate Antibiotic Use for the Respiratory Tract Infections
………N. Miyashita 1415
Safety Profile of Antimicrobial Agents
………S. Hori 1423

—Reviews—

Development and Validation of Programs for Ligand-binding-pocket Search
………A. Oda 1429
Intramolecular Cyclization Reaction of Multiple Bonds and Its Application
………F. Inagaki 1437
Blood-Brain Barrier Transport of Opioid Analgesics
………T. Suzuki 1445
Development of Environmentally Benign Transformations via 1,3-Transposition of Hydroxyl Group
………M. Egi 1453
Role of RecQ5 in Syncytial Blastoderm of the Drosophila Embryo
………H. Sakurai 1461

—Regular Articles—

Effects of Novel All-Trans Retinoic Acid Retinamide Derivatives on the Proliferation and Apoptosis of Human Lung Adenocarcinoma Cell Line A549 Cells
………S.-Y. Gui, F.-H. Chen, Q. Zhou, and Y. Wang 1465
Chemopreventive Effects of 5-Fluorouracil and Lactoferrin on Goldfish Intestinal Carcinogenesis Induced by 1,2-Dimethylhydrazine
………K. Takase and I. Kakuta 1473
Model Analysis of Tulobuterol Patch Formulations to Explain the Influence of Drug Release Rate and Transdermal Transfer Rate on the Plasma Concentration Profile
………T. Watanabe, H. Satoh, S. Hori, A. Miki, H. Ohtani, and Y. Sawada 1483
Molecular Cloning and Functional Characterization of a Novel Gene Encoding Human Prostaglandin Carrier, hPrC
………Y. Kobayashi, J. Nojima, M. Ohbayashi, N. Kohyama, and T. Yamamoto 1493
Tableting of Powdered Milk and the Resulting Physical Properties
………M. Shibata, K. Otsubo, S. Nakane, T. Niwa, and K. Danjo 1503
A Survey on the Awareness of Community Pharmacists about Raising Pharmaceutical Questions regarding Prescriptions Issued by Physicians
………Y. Shikamura, J. Takahashi, A. Oyama, K. Negishi, K. Ijyuin, N. Kamimura, and T. Aoyama 1509

—Article—

Preparation of Liposome Using Egg Yolk
………I. Sugiyama and Y. Sadzuka 1519