CONTENTS

In Japanese


—Symposium Reviews—

Advanced Approaches to Anti-aging  −Use of Aging Model Animals−
……… A. Ishigami and H. Manya 1
Antiaging Research Using Klotho Mice
……… H. Manya, K. Akasaka-Manya, and T. Endo 3
Anti-aging Studies on the Senescence Accelerated Mouse (SAM) Strains
……… R. Takahashi 11
Anti-aging Research Using Mn-SOD Conditional Knockout Mice
……… T. Shimizu and T. Shirasawa 19
Anti-aging Research Using SMP30/GNL Knockout Mice
……… A. Ishigami 25
Analysis of Aging-related Oxidative Stress Status in Normal Aging Animals and Development of Anti-aging Interventions
……… T. Sasaki 29
Development of a Technology Platform for Novel Drug Discovery Aimed at Regulating Biological Function
……… T. Nomura, H. Kayamuro, and S. Tsunoda 43
Artificial Transcription Factors Based on Multi-zinc Finger Motifs
……… T. Morisaki, M. Imanishi, S. Futaki, and Y. Sugiura 45
Enhancement of Antibody-dependent Cellular Cytotoxicity by Tandem Fc Multimerization
……… H. Nagashima and Y. Masuho 49
Application of Bioactive Mutant TNF Alpha to a Mucosal Vaccine Adjuvant
……… H. Kayamuro, Y. Yoshioka, Y. Abe, H. Kamada, S. Tsunoda, and Y. Tsutsumi 55
Creation of TNFR1-selective Antagonist and Its Therapeutic Effects
……… T. Nomura, Y. Abe, Y. Yoshioka, S. Nakagawa, S. Tsunoda, and Y. Tsutsumi 63

—Regular Articles—

Correlation of Pharmacokinetic Parameters with Serum Vancomycin Concentration in Elderly Patients with Malignancies
……… S. Sadoh, Y. Tsuji, and K. Tsukamoto 69
Preparation of Orally Disintegrating Tablets with Masking of Unpleasant Taste: Comparison with Corrective-adding Methods
……… Y. Kawano, A. Ito, M. Sasatsu, and Y. Machida 75
Preparation of Orally Disintegrating Tablets with Taste-masking Function: Masking Effect in Granules Prepared with Correctives Using the Dry Granulation Method and Evaluation of Tablets Prepared Using the Taste-masked Granules
……… Y. Kawano, A. Ito, M. Sasatsu, and Y. Machida 81
Doripenem Pharmacokinetics in Critically Ill Patients Receiving Continuous Hemodiafiltration (CHDF)
……… S. Hidaka, K. Goto, S. Hagiwara, H. Iwasaka, and T. Noguchi 87
Prediction of Incompatibility of Ceftriaxone Sodium with Calcium Ions Using the Ionic Product
……… Y. Nakai, E. Tokuyama, M. Yoshida, and T. Uchida 95

—Notes—

Preparation of PLGA Microspheres Encapsulating Highly Concentrated Glycyrrhizin and the Bile Elimination of Glycyrrhizin after Subcutaneous Administration in Rats
……… K. Ohyanagi, K. Shintani, and K. Koga 103
Pharmacokinetics of Orally Administered Tacrolimus in Lupus Nephritis Patients
……… K. Uchida, Y. Asamiya, T. Takei, M. Itabashi, H. Sugiura, M. Tsukada, and K. Nitta 113
Development of Semisolid Dosage Form of Clonazepam for Oral Cavity Administration
……… O. Sakata, H. Onishi, and Y. Machida 119
Pharmacological Assessment of ARTCEREB® Irrigation and Perfusion Solution for Cerebrospinal Surgery Based on Glucose Incorporation Activity in Primary Cultures of Rat Brain Cells
……… M. Nishimura, K. Doi, and S. Naito 127
Collecting and Sharing Information about Dietary Supplements and Functional Foods among Healthcare Professionals Using Internet-based System
……… Y. Asahina, S. Hori, and Y. Sawada 131